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Detection the Infection of HIV Paper

Detection the Infection of HIV Paper
Human rhinoviruses (HRVs) first discovered in the1950s in an effort to identifythe etiology of common cold. About 60 years later the search for a “cure” for the common coldvirus infection is still ongoing. Studies have revealed that HRV has been detected in patients with respiratory tract infections worldwide leading to considerable economic burdens in terms of medical visits and school and work absenteeism (Roelen at al., 2011, Pierangeli et al., 3013).Detection the Infection of HIV Paper
However, while once thought to cause relatively benign upper respiratory tract illness, HRVs are now linked to exacerbations of chronic pulmonary disease, asthma development, acute lower respiratory tract infections,severe bronchiolitis and pneumonia, particularly ininfants and children, as well as fatal pneumonia in elderly and immunocompromised adults (Khetsuriani et al.,2008, Cox et al., 3013). Our enhanced understanding of the spectrum of illness of HRVs draws largely from advances in molecular methods that have facilitated the detection and characterization of HRV groups and strains. Indeed, a growing number of clinical laboratories are adopting multiplex PCR-based assays for the detection of respiratory viruses that include HRVs (Pappas et al., 2008).There is currently no approved antiviral agents for the prevention or treatment of HRV infection.Detection the Infection of HIV Paper
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Clinical trials of antiviral therapies have been limited by drug toxicities, drug interactions, and a lack of efficacy when applied to the natural setting (Patick, 2006, Webster et al., 2005). To date, there have been no HRV vaccines evaluated in clinical trials. Challenges to vaccine development include the presence of more than 100 different HRV serotypes with high-level sequence variability in the antigenic sites, the lack of epidemiologicaldata to identify the most commonly circulating HRV strains (Rohde, 2011).However, a study of the VP4 protein has shown it to be highly conserved among many serotypes of Human rhinovirus (Katpally et al., 2009). The treatment of HRV infection remains primarily supportive, including over-the-counter products aimed at symptom relief. Given the frequency of HRV infections and our expanding knowledge of their clinical spectrum, effective control of this virus through treatment and prevention would have significant public health impacts.Using of molecular methods for viral detection symptomaticHRVinfection has beennoted to be relatively common, particularly in children. The frequent detection of HRV in asymptomatic individuals may alsoreflect one of several states: prolonged virus shedding after asymptomatic respiratory illness has resolved; mild, unrecognizedsymptoms.Detection the Infection of HIV Paper

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